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PERSPECTIVE

Stretching to meet needs: integrin-linked kinase and the cardiac pump

Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California at San Francisco, San Francisco, California 94158, USA

The first 100 words of the full text of this article appear below.

In an elegant set of genetic and biochemical experiments reported in this issue of Genes & Development, Bendig et al. (2006) show that integrin-linked kinase (ILK) is a critical component of the cardiac stretch sensor. Their findings link the cell surface and actin cytoskeleton to central signaling pathways. Here we discuss the significance of this work in light of other recent discoveries on the molecular mechanisms of cardiac stretch sensing.

The heart has the extraordinary capability of responding to physiologic demand by rapidly altering the amount of blood pumped with each heartbeat. Similarly, in response to pathologic conditions, the . . . [Full Text of this Article]

	Sarcomeric molecules in mechanotransduction

 

	Costameres: where the contractile apparatus meets the extracellular matrix (ECM)

 

	ILK is a novel component of the cardiac mechanical stretch sensor

 

	Questions and future perspectives

 

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