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When viral oncoprotein meets tumor suppressor: a structural view

The Wistar Institute and Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

The first 100 words of the full text of this article appear below.

In 1898, Friedrich Loeffler and Paul Frosch reported on the identification of a filterable agent that was the cause of foot and mouth disease in livestock (Levine 2001). This was the first identification of a vertebrate virus, shortly after the isolation of the tobacco mosaic virus by Dimitrii Ivanovsky in 1892 (Horzinek 1997). Since these initial discoveries, we have come to appreciate how these genetic entities that lie somewhere between the living and nonliving state survive, propagate, infect, and mediate disease. We know that in the absence of a host cell, these obligate parasites exist in a latent . . . [Full Text of this Article]

	More about viruses

 

	Two tumor suppressors that rule all

 

	Attack of viruses—part I

 

	Attack of viruses—part II

 

	p53 inactivation and beyond

 

	Design for the cure

 

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