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Some disassembly required: role of DNA translocases in the disruption of recombination intermediates and dead-end complexes

¹ Department of Microbiology, Columbia University Medical Center, New York, New York 10032, USA; ² Sections of Microbiology and of Molecular and Cellular Biology, Center for Genetics and Development, University of California at Davis, Davis, California 95616, USA

The first 100 words of the full text of this article appear below.

Homologous recombination (HR) plays essential roles in the maintenance of genome integrity in prokaryotic and eukaryotic organisms. The primary function of HR in mitotic cells is to repair double-strand breaks (DSBs) or single-strand gaps that form as a result of replication fork collapse from processing of spontaneous damage and from exposure to DNA damaging agents. During meiosis, HR is essential to establish a physical connection between homologous chromosomes to ensure their correct disjunction at the first meiotic division. In meiosis, the high levels of recombination result from the programmed introduction of DSBs throughout the genome by the Spo11 transesterase. After . . . [Full Text of this Article]

	Rad54 dissociates Rad51–dsDNA filaments: disassembling unproductive complexes and moving the pathway along

 

	Dissociation of Dmc1–dsDNA filaments by Rdh54/ Tid1: freeing up the pool of Dmc1 and release of Dmc1 from recombination intermediates?

 

	Srs2/UvrD dissociate Rad51/RecA–ssDNA filaments: reversing an early step in the pathway

 

	Dissociation of D-loops by Sgs1/BLM helicases: dynamic invasion–dissociation–reinvasion cycles in recombination?

 

	Dynamic instability of recombination intermediates and DNA complexes of recombination proteins

 

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