Genes and Development

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GENES & DEVELOPMENT 20:2487-2491, 2006
©2006 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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Packing for the germy: the role of histone H4 Ser1 phosphorylation in chromatin compaction and germ cell development

Kristy D. Wendt1 and Ali Shilatifard1,2,3

1 Department of Biochemistry, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA; 2 Saint Louis University Cancer Center, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA

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Genetic and epigenetic information is passed to the next generation through germ cells. In this issue of Genes and Development, Krishnamoorthy et al. (2006)Go have elegantly demonstrated that a conserved histone modification, phosphorylation of Ser1 on histone 4 (H4 S1ph) is involved in chromatin compaction during sporulation in yeast, and that it is an evolutionarily conserved mark found during Drosophila melanogaster and mouse germ cell development.

Post-translational modifications of core histones (PTMs) and incorporation of histone variants/replacement proteins during gametogenesis provide an exceptional example of the relationship between chromatin structure and function. In these instances, histones fulfill their more . . . [Full Text of this Article]


   H4 S1 is phosphorylated during sporulation, and unlike H3 S10ph, appears to be a stable modification
 

   H4 S1 is phosphorylated in an Sps1-dependent manner during sporulation
 

   Phosphorylation of H4 S1 can regulate nuclear volume, chromatin compaction, and accessibility
 

   H4 S1ph is a conserved histone modification of metazoans
 

   Possible mechanisms for the role of H4 S1ph in chromatin compaction during sporulation and spermatogenesis
 

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Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis
Thanuja Krishnamoorthy, Xin Chen, Jerome Govin, Wang L. Cheung, Jean Dorsey, Karen Schindler, Edward Winter, C. David Allis, Vincent Guacci, Saadi Khochbin, Margaret T. Fuller, and Shelley L. Berger
Genes & Dev. 2006 20: 2580-2592. [Abstract] [Full Text] [PDF]





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