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Sister chromatid cohesion in silent chromatin: each sister to her own ring

Department of Cell Biology, Harvard Medical School, Boston Massachusetts 02115, USA

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The proper transmission of genetic material is crucial for the growth and survival of all organisms. Each time a eukaryotic cell divides, it must faithfully produce two copies of each chromosome, known as sister chromatids, and accurately distribute them between two daughter cells. To ensure their faithful transmission, newly replicated sister chromatids must be held together long enough to allow proper bipolar attachment to microtubules and alignment on the metaphase spindle. Cohesion of sister chromatids is mediated by cohesin, an evolutionarily conserved, multiprotein complex that is associated with chromosome arms and is highly enriched at the centromeres of chromosomes (Hagstrom . . . [Full Text of this Article]

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