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Perspective

Denoising feedback loops by thresholding—a new role for microRNAs

European Molecular Biology Laboratory, 69117 Heidelberg, Germany

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It is almost axiomatic that precision in spatial and temporal control of gene expression is important for organogenesis. Our appreciation of this notion derives in part from studies of the developing sensory nervous system in Drosophila (for review, see Modolell 1997). In this issue of Genes & Development, Gao and coworkers (Li et al. 2006) add an exciting new twist to this story, showing that post-transcriptional gene regulation by the microRNA miR-9a plays an important role in ensuring the precision of sense organ specification in Drosophila.

microRNAs (miRNAs) have gained considerable attention recently as negative post-transcriptional . . . [Full Text of this Article]

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MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila

Yan Li, Fay Wang, Jin-A Lee, and Fen-Biao Gao
Genes & Dev. 2006 20: 2793-2805. [Abstract] [Full Text] [PDF]

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