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GENES & DEVELOPMENT 20:2773-2778, 2006
©2006 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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Perspective

spineless provides a little backbone for dendritic morphogenesis

Stephen T. Crews1,3 and Jay E. Brenman2

1 Department of Biochemistry and Biophysics, Department of Biology, and Program in Molecular Biology and Biotechnology, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA; 2 Department of Cell and Developmental Biology and Neuroscience Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA

The first 100 words of the full text of this article appear below.

I've got my spine. I've got my orange crush.

—REM, "Orange Crush"

In the brain, information processing occurs as synapses relay information through neuronal circuits. Most of these synaptic connections physically form on neuronal dendrites—highly specialized subcellular structures that receive and integrate information. Although most dendrites form connections with other neurons, other dendrites, like those found on sensory neurons, receive information directly from the external environment. Highly elaborate and branched dendrites form expansive surface areas for receiving inputs—a feature that distinguishes neurons as one of the most unique and readily identifiable cell types. However, despite the complexity and dramatic . . . [Full Text of this Article]


    The Drosophila peripheral nervous system (PNS) and dendritic morphology
 

    Regulation of Drosophila dendrite development
 

    Role of spineless in dendritic morphology
 

    Genetic and biochemical functions of Ss and Ahr
 

Vertebrate Ahr


C. elegans ahr-1


    Concluding remarks
 

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Related Article

The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons
Michael D. Kim, Lily Yeh Jan, and Yuh Nung Jan
Genes & Dev. 2006 20: 2806-2819. [Abstract] [Full Text] [PDF]



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