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Dosage compensation in high resolution: global up-regulation through local recruitment

Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland

The first 100 words of the full text of this article appear below.

Dosage compensation solves the chromosomal imbalance that is a result of sexual determination by sex chromosomes. It equalizes gene expression between the homogametic (XX) and heterogametic (XY) sexes and thus needs to selectively modify expression from the X chromosome in a sex-specific manner without affecting transcription on the autosomes. Various strategies have evolved in different organisms to achieve this balance, and their study has contributed significantly to our understanding of transcriptional gene regulation of whole chromosomes and established several paradigms of epigenetic control (Lucchesi 1998; Stuckenholz et al. 1999; Akhtar 2003).

In mammals, dosage compensation is accomplished . . . [Full Text of this Article]

	Local recruitment—chromosome-wide up-regulation?

 

	Developmental dynamics of DCC binding

 

	Up-regulation by binding downstream of the promoter

 

	Targeting of DCC

 

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