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PERSPECTIVE

Determinants of regulated proteolysis in signal transduction

¹ Zentrum für Medizinische Biotechnologie, Universität Duisburg-Essen, 45117 Essen, Germany; ² School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom

The first 100 words of the full text of this article appear below.

Each cell produces thousands of gene products that differ in cellular localization, chemical properties, interactions with other cellular factors, abundance, and half lives. Controlling these events presents an enormous organizational challenge. In recent years, biological quality-control systems were identified addressing this problem. The importance of these systems is underlined by the facts that several quality-control factors are essential for viability and are directly implicated in many severe diseases, such as cancer, cystic fibrosis, amyloid, and autoimmune diseases.

Protein quality control is in charge of the regulation of protein composition by ensuring that individual proteins are synthesized when needed, are properly . . . [Full Text of this Article]

	The components involved in signal sensing and signal transduction

 

	The mechanism of signal sensing and signal transduction

 

The signal

	The proteolytic cascade

 

Step 1: initial processing of RseA by DegS

Step 2: RseA^1–148 is further processed by RseP

Step 3: RseA^1–108 is degraded by cytoplasmic proteases

Step 4: ^E modulates expression of target promoters

	Conclusions and implications

 

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