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PERSPECTIVE

YY1 helps to bring loose ends together

¹ Departments of Microbiology and Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, New York 10032, USA; ² Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104, USA

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Ubiquitously expressed transcription factor Yin Yang 1 (YY1) has long been believed to play some role in immunoglobulin gene regulation, because it associates with multiple Ig enhancer elements including the heavy-chain intron and 3' enhancers as well as the Ig 3' enhancer (Park and Atchison 1991; Gordon et al. 2003). Early on, YY1 was noted to have bifunctional properties, in that it could either repress or activate transcription, depending on binding site context, protein interactions, or levels within the cell (Park and Atchison 1991; Seto et al. 1991; Shi et al. 1991; Lee et al. . . . [Full Text of this Article]

	VH-DHJH recombination

 

	Cis-acting elements in the IgH locus and the proteins that bind them

 

	Transcription of unrearranged gene segments

 

	Changes in chromatin structure of the IgH locus

 

	YY1 and VH-DHJH recombination

 

	Additional YY1 functions in B-cell development

 

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