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PERSPECTIVE

PTB/nPTB switch: a post-transcriptional mechanism for programming neuronal differentiation

¹ Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA; ² College of Life Sciences, Wuhan University, Wuhan 430072, People’s Republic of China

The first 100 words of the full text of this article appear below.

Neuronal differentiation involves extensive reprogramming of gene expression. Many neuronal-specific genes are actively repressed in nonneuronal cells, while many others are induced in response to cell differentiation cues. Together these constitute the transcriptome in neurons to instruct specific neuronal functions (Rosenfeld et al. 2006). The transcriptome in neurons is further diversified by alternative splicing, arising from the expression of a number of neuronal-specific RNA-binding splicing regulators (Black and Grabowski 2003). In this issue of Genes & Development, Boutz et al. (2007b) report a novel switch in the expression of a pair of related splicing regulators that occurs . . . [Full Text of this Article]

	Splicing control by PTB

 

	PTB regulation of nPTB expression

 

	Splicing reprogramming induced by the PTB/nPTB switch

 

	Transcriptional and post-transcriptional induction of the neuronal splicing program

 

	The road ahead: linking regulated splicing to neuronal phenotype

 

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