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GENES & DEVELOPMENT 21:1983-1988, 2007
©2007 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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PERSPECTIVE

Life beyond cleavage: the case of Ago2 and hematopoiesis

Javier Martinez1 and Meinrad Busslinger2,3

1 Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), A-1030 Vienna, Austria; 2 Research Institute of Molecular Pathology, Vienna Biocenter, A-1030 Vienna, Austria

The first 100 words of the full text of this article appear below.

A recent article in The Economist (June 16, 2007) describes research on RNA as the 21st century’s Big Bang in biology. The "stars" of the RNA universe are small regulatory RNAs known as microRNAs (miRNAs). These ~22-nt-long RNAs were discovered in 1993 (Lee et al. 1993Go; Wightman et al. 1993Go), but their role in biology remained obscure until 2001, when the Tuschl, Ambros, and Bartel laboratories identified hundreds of miRNAs in different organisms (Lagos-Quintana et al. 2001Go; Lau et al. 2001Go; Lee and Ambros 2001Go). Functional analyses of these miRNAs and their associated complexes subsequently . . . [Full Text of this Article]


   MicroRNAs in hematopoietic development
 

   Essential function of Ago2 in erythroid and B cell development
 

   Control of miRNA biogenesis by Argonaute proteins
 

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Related Article

A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway
Dónal O’Carroll, Ingrid Mecklenbrauker, Partha Pratim Das, Angela Santana, Ulrich Koenig, Anton J. Enright, Eric A. Miska, and Alexander Tarakhovsky
Genes & Dev. 2007 21: 1999-2004. [Abstract] [Full Text] [PDF]





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