Genes and Development

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GENES & DEVELOPMENT 21:2677-2682, 2007
©2007 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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Rho deep in thought

Rachel McMullan and Stephen J. Nurrish1

Medical Research Council (MRC) Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Department of Pharmacology, University College, London WC1E 6BT, United Kingdom

The first 100 words of the full text of this article appear below.

Neuronal communication underlies all aspects of brain function, including learning, memory, and consciousness. How neurons communicate is controlled by both the formation of neuronal connections during neural development and the regulation of neuronal activity in the adult brain. Rho GTPases have a well-known role in neuronal development, and recent studies published in Genes & Development (Steven et al. 2005Go; McMullan et al. 2006Go) have demonstrated that they also regulate neuronal activity in the adult brain—at least in Caenorhabditis elegans. Rho in C. elegans acts as part of a network of G{alpha}q pathways that increase neuronal activity by . . . [Full Text of this Article]


   G{alpha}o and G{alpha}q antagonistically control neuronal activity
 

   G{alpha}o and G{alpha}q antagonistically regulate levels of DAG
 

   RHO-1 regulates neuronal activity
 

   Multiple RhoGEFs regulate neuronal activity
 

   Does G{alpha}q signal via PLCbeta EGL-8 and UNC-73RhoGEF in the same cells?
 

   There is still a lot we do not know about G-protein regulation of neuronal activity
 

   A model for the human brain?
 

   The worm has a lot more to tell us
 

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Related Article

Trio’s Rho-specific GEF domain is the missing G{alpha}q effector in C. elegans
Stacey L. Williams, Susanne Lutz, Nicole K. Charlie, Christiane Vettel, Michael Ailion, Cassandra Coco, John J.G. Tesmer, Erik M. Jorgensen, Thomas Wieland, and Kenneth G. Miller
Genes & Dev. 2007 21: 2731-2746. [Abstract] [Full Text] [PDF]



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