Genes and Development

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GENES & DEVELOPMENT 21:2845-2849, 2007
©2007 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis

Bob Argiropoulos1, Eric Yung1, and R. Keith Humphries1,2,3

1 Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; 2 Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

The first 100 words of the full text of this article appear below.

The "cancer stem cell" hypothesis has emerged as the leading paradigm in how we view the origin and perpetuation of neoplastic-initiating cells in leukemia and solid tumors (for review, see Buzzeo et al. 2007Go). Central to this model is the concept that only a rare subpopulation of cells in the malignant clone retains or acquires the ability to self-renew and proliferate to initiate and maintain the disease. Although hematopoietic stem cells (HSC) with inherent self-renewal properties are generally believed to be the initiating cells for malignant transformation in acute leukemias, it is now evident that the target stem cell . . . [Full Text of this Article]


   The crucial role of Meis1 in MLL-induced leukemia
 

   Meis1 is a potent collaborative gene in leukemia
 

   On the road to uncovering the molecular mechanisms underlying Meis1 function
 

   The role of Meis1 in normal hematopoiesis
 

   Meis1: a force to be reckoned with
 

   Meis1: a knockout punch for leukemia
 

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Related Article

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
Piu Wong, Masayuki Iwasaki, Tim C.P. Somervaille, Chai Wai Eric So, and Michael L. Cleary
Genes & Dev. 2007 21: 2762-2774. [Abstract] [Full Text] [PDF]





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Copyright © 2007 by Cold Spring Harbor Laboratory Press.