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RecQ helicases queuing with Srs2 to disrupt Rad51 filaments and suppress recombination

Fondazione Italiana Ricerca sul Cancro (FIRC) Institute of Molecular Oncology Foundation, 20139 Milan, Italy; Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, 20133 Milan, Italy

The first 100 words of the full text of this article appear below.

Homologous recombination (HR) is an important mechanism for the maintenance of genome integrity. HR functions to repair double-strand breaks (DSBs) and single-strand gaps formed during replication or created by DNA damaging agents or from processing DNA lesions. In addition, HR is implicated in the restart of damaged replication forks and functions in telomere length maintenance in cells lacking telomerase. Increasing evidence suggests that HR plays an important role in cancer prevention (Thompson and Schild 2002; Sung and Klein 2006). However, recombination can also be harmful and have oncogenic and mutagenic consequences. It is known that inappropriate or untimely . . . [Full Text of this Article]

	BLM’s role in controlling HR and suppressing SCE formation

 

	RecQ helicases and Srs2 in suppressing recombination

 

	Similarities and dissimilarities between BLM, RecQL5, and Srs2

 

	RecQL5 role in SCE

 

	Dissociation of D-loops by Sgs1/BLM: relevance for promoting SDSA and preventing SCE

 

	Protein interactions and RecQ-like helicases in controlling recombination

 

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				O. Aygun, J. Svejstrup, and Y. Liu A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin PNAS, June 24, 2008; 105(25): 8580 - 8584. [Abstract] [Full Text] [PDF]