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Enhancing togetherness: kinetochores and cohesion

Stowers Institute for Medical Research and University of Kansas Medical Center, Kansas City, Missouri 64110, USA

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All organisms must correctly copy and equally distribute their genetic information each and every time a new cell is created. In eukaryotic cells, this action involves many different coordinated processes, including DNA replication, kinetochore and spindle formation, and chromosome cohesion. If errors occur in chromosome segregation, a chromosome may be lost or gained, resulting in an aneuploid cell. Aneuploidy is associated with cancer in humans, as well as a variety of developmental disorders including Downs syndrome. Because all organisms require the faithful transmission of their genetic information, many of these processes and proteins are evolutionarily conserved. Thus, gaining a basic . . . [Full Text of this Article]

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