QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zou, L. Search for Related Content PubMed PubMed Citation Articles by Zou, L. Related Content DNA Replication, Recombination, and Repair Related Article Social Bookmarking                   What's this?

PERSPECTIVE

Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response

Massachusetts General Hospital Cancer Center and Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129, USA

The first 100 words of the full text of this article appear below.

The DNA damage signaling pathways mediated by the ataxia-telangiectasia mutated (ATM) and the ATM and Rad3-related (ATR) kinases play crucial roles in the maintenance of genomic integrity and may function as an anti-cancer barrier during early tumorigenesis. Although the ATM and ATR pathways share some of their downstream functions, the DNA damage that evoke these two pathways are distinct. While ATM plays a primary role in the response to double-stranded DNA breaks (DSBs), ATR controls the response to a much broader spectrum of DNA damage, including many that interfere with DNA replication. And, unlike ATM, ATR is crucial for maintaining . . . [Full Text of this Article]

	Hints from yeast, Xenopus, and human

 

	Defining the ATR checkpoint-activating DNA structure

 

	The functions of ssDNA and ds/ssDNA junctions

 

	Quantitative control of DNA damage signals

 

	A multistep model for ATR checkpoint activation

 

	Beyond the minimal DNA structure for checkpoint activation

 

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Article

The structural determinants of checkpoint activation

Christina A. MacDougall, Tony S. Byun, Christopher Van, Muh-ching Yee, and Karlene A. Cimprich
Genes & Dev. 2007 21: 898-903. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

				J.-H. Choi, L. A. Lindsey-Boltz, and A. Sancar Reconstitution of a human ATR-mediated checkpoint response to damaged DNA PNAS, August 14, 2007; 104(33): 13301 - 13306. [Abstract] [Full Text] [PDF]

				L. A. Lindsey-Boltz and A. Sancar RNA polymerase: The most specific damage recognition protein in cellular responses to DNA damage? PNAS, August 14, 2007; 104(33): 13213 - 13214. [Full Text] [PDF]