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PERSPECTIVE

New ways to meet your (3') end—oligouridylation as a step on the path to destruction

Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA

The first 100 words of the full text of this article appear below.

Messenger RNA degradation is a vital contributor to the control of gene expression that generally involves removal of a poly(A) tail in both prokaryotes and eukaryotes. In a thought-provoking study in this issue of Genes & Development, Mullen and Marzluff (2008) present data supporting a novel mechanism of mRNA decay. They discovered that histone mRNAs, which are unique in that they are never polyadenylated in mammalian cells, degrade by a cell cycle-regulated mechanism that involves addition of a short oligo(U) tail at the 3' end. Interestingly, this oligo(U) tract is recognized by the Lsm1–7 complex, which then appears to . . . [Full Text of this Article]

	Multiple ways to add and remove poly(A)

 

Bacterial polyadenylation and mRNA decay

Eukaryotic polyadenylation and mRNA decay

Other PAPs in eukaryotes

GLD2, a cytoplasmic PAP
TRAMP—an RNA surveillance mechanism
Mitochondrial PAP
U6 TUTase—not a PAP at all
PAPs in Pombe

	Oligouridylation of histone mRNAs

 

	Questions for the future

 

	Conclusions and perspective

 

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Related Article

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'

Thomas E. Mullen and William F. Marzluff
Genes & Dev. 2008 22: 50-65. [Abstract] [Full Text] [PDF]