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GENES & DEVELOPMENT 22:279-285, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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PERSPECTIVE

The search for alternative splicing regulators: new approaches offer a path to a splicing code

Charles J. David and James L. Manley1

Department of Biological Sciences, Columbia University, New York, New York 10027, USA

The first 100 words of the full text of this article appear below.

Complex multicellular organisms require a diverse set of proteins to set the form and function of specialized cell types. The availability of complete genomic sequences has revealed that instead of a large increase in the number of protein coding genes compared with unicellular organisms, more complex eukaryotes instead obtain more diversity out of a relatively limited number of genes through the process of alternative splicing (AS). AS results in the cell type-, developmental stage-, sex-, or signal-regulated changes in composition of an mRNA produced from a given gene, brought about by changes in splice site choice (Black 2003Go; Matlin . . . [Full Text of this Article]


   Known AS regulators
 

   A genetic approach to identifying AS regulators in C. elegans
 

   Three conserved splicing regulators identified in another AS event
 

   From the identification of AS regulators to a cellular code of AS regulation
 

   Conclusions and perspectives
 

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Related Article

STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo
Genta Ohno, Masatoshi Hagiwara, and Hidehito Kuroyanagi
Genes & Dev. 2008 22: 360-374. [Abstract] [Full Text] [PDF]





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