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GENES & DEVELOPMENT 22:293-296, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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Tailored Hox gene transcription and the making of the thumb

Jacqueline Deschamps1

Hubrecht Institute, Developmental Biology and Stem Cell Research, Utrecht 3584 CT, The Netherlands

The first 100 words of the full text of this article appear below.

As soon as the Hox genes were isolated in Drosophila and identified in mammals more than two decades ago, genetic and molecular data started to accumulate, suggesting a conserved function for these clustered genes in the specification of positional identity of rostro–caudal embryonic structures (Duboule and Dollé 1989Go; Graham et al. 1989Go). Temporal and spatial collinearity of expression of the Hox genes was shown to correlate with the anterior to posterior progression of development, with 3' genes being expressed earlier and more anteriorly than successively more 5' genes. Shortly after these discoveries, overlapping expression patterns of the 5' . . . [Full Text of this Article]


   Hoxd gene expression: late limb collinearity opposite to axial collinearity
 

   Unique Hox expression status and morphology of the thumb
 

   Strict quantitative control of 5' Hoxd transcription
 

   A mathematical model able to account for the Hoxd expression features
 

   Hoxd expression in the genital bud fits the limb model
 

   Untangling multiple control strategies of the clustered Hox genes
 

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Genes & Dev. 2008 22: 286-292. [Extract] [Full Text] [PDF]





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