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GENES & DEVELOPMENT 22:693-699, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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PERSPECTIVE

BMPs oppose Math1 in cerebellar development and in medulloblastoma

Matthew R. Grimmer and William A. Weiss1

Department of Neurology, Department of Pediatrics, and Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143, USA

The first 100 words of the full text of this article appear below.

Bone morphogenetic proteins (BMPs) are soluble effectors of differentiation and are central in orchestrating development of organs including the cerebellum. The transcription factor and BMP target Math1 (mouse atonal homolog 1) is a critical regulator of neuronal progenitors destined to form the cerebellar cortex. Signaling networks controlled by BMPs, Math1, and Sonic Hedgehog (Shh) together regulate the proliferation and differentiation of cerebellar progenitor cells. Defects in these pathways are also implicated in medulloblastoma, the most common pediatric brain tumor. In this issue of Genes & Development, Zhao et al. (2008)Go perform an elegant set of experiments that clarify the . . . [Full Text of this Article]


   A primer on cerebellar development
 

   Proliferation of GNPs is regulated by Shh and Math1
 

   BMPs interact with Math1 to coordinate cell fate
 

   Smad proteins transduce BMP signals to the nucleus
 

   BMPs, Math1, and Shh in medulloblastoma
 

   Can BMPs be used therapeutically in medulloblastoma?
 

   Future directions
 

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Related Article

Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development
Haotian Zhao, Olivier Ayrault, Frederique Zindy, Jee-Hae Kim, and Martine F. Roussel
Genes & Dev. 2008 22: 722-727. [Abstract] [Full Text] [PDF]





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