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GENES & DEVELOPMENT 22:706-710, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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A house with many rooms: how the heart got its chambers with foxn4

Ethan David Cohen1 and Edward E. Morrisey1,2,3,4

1 Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; 2 Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; 3 Department of Medicine and Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

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The vertebrate heart is initially formed from two lateral domains of cardiogenic mesoderm that fuse at the ventral midline to form a simple heart tube that is similar to the hearts or dorsal vessels of invertebrates. As development proceeds, this initial heart tube undergoes a series of morphogenetic rearrangements that subdivides the heart into the distinct chambers found in adult vertebrates. In this issue of Genes & Development, Chi et al. (2008)Go describe a novel transcriptional pathway required for separation of the outflow (ventricular) portion from the inflow (atrial) portion of the two-chambered zebrafish heart. This separation takes place . . . [Full Text of this Article]


   Development and function of the AV canal and foxn4
 

   Fox genes and cardiac development
 

   A Fox–Tbx pathway in cardiac development
 

   Fine-tuning AV canal development: implications for higher vertebrates
 

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Related Article

Foxn4 directly regulates tbx2b expression and atrioventricular canal formation
Neil C. Chi, Robin M. Shaw, Sarah De Val, Guson Kang, Lily Y. Jan, Brian L. Black, and Didier Y.R. Stainier
Genes & Dev. 2008 22: 734-739. [Abstract] [Full Text] [PDF]





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