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GENES & DEVELOPMENT 22:700-705, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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PERSPECTIVE

Micromanaging regeneration

Elly M. Tanaka1,2 and Gilbert Weidinger1,3,4

1 Center for Regenerative Therapies, 01307 Dresden, Germany; 2 Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany; 3 Biotechnology Center of the Technical University Dresden, 01307 Dresden, Germany

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All adult animals are capable of maintaining their shape and function by homeostatic replacement of dying cells, but their ability to regenerate lost or damaged organs and appendages varies widely. Unfortunately for us humans, mammals are found at the lower end of the vertebrate spectrum. We can regrow large parts of the liver and pancreas, repair limited damage to skeletal muscle and peripheral nervous system, but pale in comparison with the amazing capacity of amphibia and fish to repair most organs, including lens, retina, heart muscle, and CNS, and to even regrow amputated limbs and fins. After more than 100 . . . [Full Text of this Article]


   Regenerating adult tissues retain cell plasticity
 

   Multiple molecular signaling cascades are implemented during regeneration
 

   MicroRNAs (miRNAs) in development, cell differentiation, and tissue function
 

   A role of miR-133 in regeneration
 

   Mps1 kinase is an in vivo target of miR-133
 

   What is the significance and specificity of miR-133 in regenerative outgrowth?
 

   Are miRNAs a means of retaining growth potential in adult tissue?
 

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Related Article

Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish
Viravuth P. Yin, J. Michael Thomson, Ryan Thummel, David R. Hyde, Scott M. Hammond, and Kenneth D. Poss
Genes & Dev. 2008 22: 728-733. [Abstract] [Full Text] [PDF]





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