Erratum

Genes & Development 21: 694–707 (2007)

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

Alice T. Shaw, Alexander Meissner, James A. Dowdle, Denise Crowley, Margaret Magendantz, Chensi Ouyang, Tiziana Parisi, Jayaraj Rajagopal, Leah J. Blank, Roderick T. Bronson, James R. Stone, David A. Tuveson, Rudolf Jaenisch, and Tyler Jacks

The authors wish to report an inadvertent error in the genetic backgrounds of the mice shown in Figure 7, C–F, involving strain imbalance and propagation of a tetOCre transgene with the Spry-2^Fl allele. They have repeated the experiment using new cohorts of compound mutants lacking tetOCre. The corrected figure is shown below. Of note, at 12 wk after Ad-Cre infection, the total number of tumors as well as overall tumor burden were both increased in LSL-K-ras^G12D; Spry-2^Fl/Fl mice (n = 4) compared with LSL-K-ras^G12D; Spry-2^Fl/+ controls (n = 7), although the difference was not statistically significant (Fig. 7C; data not shown). However, there was a statistically significant increase in the size of lung tumors lacking Spry-2 (n = 255) compared with control tumors (n = 243) (Fig. 7C,D). In addition, there was also a trend toward increased pErk staining in the absence of Spry-2 (Fig. 7E,F), as shown previously. This correction does not change the major findings or conclusions of the study.

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