![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 14, No. 1, pp. 23-27, January 1, 2000
1 Departments of Medicine and Pathology, Howard Hughes
Medical Institute, Washington University School of Medicine, St. Louis,
Missouri 63110 USA; 2 Dana-Farber Cancer Institute, Harvard
Medical School, Boston, Massachusetts 02115 USA
We disrupted the Mcl-1 locus in murine ES cells to
determine the developmental roles of this Bcl-2 family member.
Deletion of Mcl-1 resulted in peri-implantation embryonic
lethality. Mcl-1
/ embryos do
not implant in utero, but could be recovered at E3.5-4.0. Null
blastocysts failed to hatch or attach in vitro, indicating a
trophectoderm defect, although the inner cell mass could grow in
culture. Of note, Mcl-1/
blastocysts showed no evidence of increased apoptosis, but exhibited a
delay in maturation beyond the precompaction stage. This model indicates that Mcl-1 is essential for preimplantation
development and implantation, and suggests that it has a function
beyond regulating apoptosis.
[Key Words: Mcl-1; apoptosis; implantation; embryo; blastocyst; Bcl-2 family]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Dzhagalov, A. Dunkle, and Y.-W. He The Anti-Apoptotic Bcl-2 Family Member Mcl-1 Promotes T Lymphocyte Survival at Multiple Stages J. Immunol., July 1, 2008; 181(1): 521 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Arbour, J. L. Vanderluit, J. N. Le Grand, A. Jahani-Asl, V. A. Ruzhynsky, E. C. C. Cheung, M. A. Kelly, A. E. MacKenzie, D. S. Park, J. T. Opferman, et al. Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage J. Neurosci., June 11, 2008; 28(24): 6068 - 6078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Subramaniam, G. Natarajan, S. Ramalingam, I. Ramachandran, R. May, L. Queimado, C. W. Houchen, and S. Anant Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2 Am J Physiol Gastrointest Liver Physiol, April 1, 2008; 294(4): G1025 - G1032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. F. Lee, P. E. Czabotar, M. F. van Delft, E. M. Michalak, M. J. Boyle, S. N. Willis, H. Puthalakath, P. Bouillet, P. M. Colman, D. C.S. Huang, et al. A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation J. Cell Biol., January 28, 2008; 180(2): 341 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nguyen, R. C. Marcellus, A. Roulston, M. Watson, L. Serfass, S. R. Murthy Madiraju, D. Goulet, J. Viallet, L. Belec, X. Billot, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis PNAS, December 4, 2007; 104(49): 19512 - 19517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Germain and V. Duronio The N Terminus of the Anti-apoptotic BCL-2 Homologue MCL-1 Regulates Its Localization and Function J. Biol. Chem., November 2, 2007; 282(44): 32233 - 32242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Chen, P.-S. Wu, C.-H. Chou, Y.-T. Yan, H. Liu, S.-Y. Weng, and H.-F. Yang-Yen A Knockout Mouse Approach Reveals that TCTP Functions as an Essential Factor for Cell Proliferation and Survival in a Tissue- or Cell Type-specific Manner Mol. Biol. Cell, July 1, 2007; 18(7): 2525 - 2532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kobayashi, S.-H. Lee, X. W. Meng, J. L. Mott, S. F. Bronk, N. W. Werneburg, R. W. Craig, S. H. Kaufmann, and G. J. Gores Serine 64 Phosphorylation Enhances the Antiapoptotic Function of Mcl-1 J. Biol. Chem., June 22, 2007; 282(25): 18407 - 18417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Ding, X. He, J.-M. Hsu, W. Xia, C.-T. Chen, L.-Y. Li, D.-F. Lee, J.-C. Liu, Q. Zhong, X. Wang, et al. Degradation of Mcl-1 by {beta}-TrCP Mediates Glycogen Synthase Kinase 3-Induced Tumor Suppression and Chemosensitization Mol. Cell. Biol., June 1, 2007; 27(11): 4006 - 4017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Czabotar, E. F. Lee, M. F. van Delft, C. L. Day, B. J. Smith, D. C. S. Huang, W. D. Fairlie, M. G. Hinds, and P. M. Colman Structural insights into the degradation of Mcl-1 induced by BH3 domains PNAS, April 10, 2007; 104(15): 6217 - 6222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Mohammad, A. S. Goustin, A. Aboukameel, B. Chen, S. Banerjee, G. Wang, Z. Nikolovska-Coleska, S. Wang, and A. Al-Katib Preclinical Studies of TW-37, a New Nonpeptidic Small-Molecule Inhibitor of Bcl-2, in Diffuse Large Cell Lymphoma Xenograft Model Reveal Drug Action on Both Bcl-2 and Mcl-1 Clin. Cancer Res., April 1, 2007; 13(7): 2226 - 2235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Dzhagalov, A. St. John, and Y.-W. He The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages Blood, February 15, 2007; 109(4): 1620 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Sitailo, S. S. Tibudan, and M. F. Denning The Protein Kinase C{delta} Catalytic Fragment Targets Mcl-1 for Degradation to Trigger Apoptosis J. Biol. Chem., October 6, 2006; 281(40): 29703 - 29710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Chou, R.-S. Lee, and H.-F. Yang-Yen An Internal EELD Domain Facilitates Mitochondrial Targeting of Mcl-1 via a Tom70-dependent Pathway Mol. Biol. Cell, September 1, 2006; 17(9): 3952 - 3963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Clohessy, J. Zhuang, J. de Boer, G. Gil-Gomez, and H. J. M. Brady Mcl-1 Interacts with Truncated Bid and Inhibits Its Induction of Cytochrome c Release and Its Role in Receptor-mediated Apoptosis J. Biol. Chem., March 3, 2006; 281(9): 5750 - 5759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Henson, X. Hu, and S. B. Gibson Herceptin Sensitizes ErbB2-Overexpressing Cells to Apoptosis by Reducing Antiapoptotic Mcl-1 Expression Clin. Cancer Res., February 1, 2006; 12(3): 845 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Liu, P. Eksarko, V. Temkin, G. K. Haines III, H. Perlman, A. E. Koch, B. Thimmapaya, and R. M. Pope Mcl-1 Is Essential for the Survival of Synovial Fibroblasts in Rheumatoid Arthritis J. Immunol., December 15, 2005; 175(12): 8337 - 8345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Balakrishnan, W. G. Wierda, M. J. Keating, and V. Gandhi Mechanisms of Cell Death of Chronic Lymphocytic Leukemia Lymphocytes by RNA-Directed Agent, 8-NH2-Adenosine Clin. Cancer Res., September 15, 2005; 11(18): 6745 - 6752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hutcheson, J. C. Scatizzi, E. Bickel, N. J. Brown, P. Bouillet, A. Strasser, and H. Perlman Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis J. Exp. Med., June 20, 2005; 201(12): 1949 - 1960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Gelinas and E. White BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis Genes & Dev., June 1, 2005; 19(11): 1263 - 1268. [Full Text] [PDF]
|
|
|
|
|
|
S. N. Willis, L. Chen, G. Dewson, A. Wei, E. Naik, J. I. Fletcher, J. M. Adams, and D. C.S. Huang Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins Genes & Dev., June 1, 2005; 19(11): 1294 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Oberdoerffer, C. Kanellopoulou, V. Heissmeyer, C. Paeper, C. Borowski, I. Aifantis, A. Rao, and K. Rajewsky Efficiency of RNA Interference in the Mouse Hematopoietic System Varies between Cell Types and Developmental Stages Mol. Cell. Biol., May 15, 2005; 25(10): 3896 - 3905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Han, L. A. Goldstein, B. R. Gastman, A. Rabinovitz, and H. Rabinowich Disruption of Mcl-1{middle dot}Bim Complex in Granzyme B-mediated Mitochondrial Apoptosis J. Biol. Chem., April 22, 2005; 280(16): 16383 - 16392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Liu, H.-W. Peng, Y.-S. Cheng, H. S. Yuan, and H.-F. Yang-Yen Stabilization and Enhancement of the Antiapoptotic Activity of Mcl-1 by TCTP Mol. Cell. Biol., April 15, 2005; 25(8): 3117 - 3126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Langenau, C. Jette, S. Berghmans, T. Palomero, J. P. Kanki, J. L. Kutok, and A. T. Look Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish Blood, April 15, 2005; 105(8): 3278 - 3285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamane, S. J. Dylla, M. Muijtjens, and I. L. Weissman Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal PNAS, March 1, 2005; 102(9): 3312 - 3317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Opferman, H. Iwasaki, C. C. Ong, H. Suh, S.-i. Mizuno, K. Akashi, and S. J. Korsmeyer Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells Science, February 18, 2005; 307(5712): 1101 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Day, L. Chen, S. J. Richardson, P. J. Harrison, D. C. S. Huang, and M. G. Hinds Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands J. Biol. Chem., February 11, 2005; 280(6): 4738 - 4744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jurisicova and B. M Acton Deadly decisions: the role of genes regulating programmed cell death in human preimplantation embryo development Reproduction, September 1, 2004; 128(3): 281 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Han, L. A. Goldstein, B. R. Gastman, C. J. Froelich, X.-M. Yin, and H. Rabinowich Degradation of Mcl-1 by Granzyme B: IMPLICATIONS FOR Bim-MEDIATED MITOCHONDRIAL APOPTOTIC EVENTS J. Biol. Chem., May 21, 2004; 279(21): 22020 - 22029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kitada and J. C. Reed MCL-1 Promoter Insertions Dial-Up Aggressiveness of Chronic Leukemia J Natl Cancer Inst, May 5, 2004; 96(9): 642 - 643. [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, M. Dong, L. Li, Y. Fan, P. Pathre, J. Dong, D. Lou, J. M. Wells, D. Olivares-Villagomez, L. Van Kaer, et al. Endonuclease G is required for early embryogenesis and normal apoptosis in mice PNAS, December 23, 2003; 100(26): 15782 - 15787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Nijhawan, M. Fang, E. Traer, Q. Zhong, W. Gao, F. Du, and X. Wang Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation Genes & Dev., June 15, 2003; 17(12): 1475 - 1486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Wang, M.-Z. Lai, and H.-F. Yang-Yen Interleukin-3 Stimulation of mcl-1 Gene Transcription Involves Activation of the PU.1 Transcription Factor through a p38 Mitogen-Activated Protein Kinase-Dependent Pathway Mol. Cell. Biol., March 15, 2003; 23(6): 1896 - 1909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Villunger, C. Scott, P. Bouillet, and A. Strasser Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival Blood, March 15, 2003; 101(6): 2393 - 2400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. Pedersen, S. Kitada, L. M. Leoni, J. M. Zapata, J. G. Karras, N. Tsukada, T. J. Kipps, Y. S. Choi, F. Bennett, and J. C. Reed Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1 Blood, August 13, 2002; 100(5): 1795 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Hartley, R. A. L. Bayne, L. L. L. Robinson, N. Fulton, and R. A. Anderson Developmental Changes in Expression of Myeloid Cell Leukemia-1 in Human Germ Cells during Oogenesis and Early Folliculogenesis J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3417 - 3427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhang, I. Gojo, and R. G. Fenton Myeloid cell factor-1 is a critical survival factor for multiple myeloma Blood, March 15, 2002; 99(6): 1885 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang, W. Holzgreve, and C. De Geyter Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway Hum. Mol. Genet., October 1, 2001; 10(21): 2329 - 2339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Liu, H. Perlman, L. J. Pagliari, and R. M. Pope Constitutively Activated Akt-1 Is Vital for the Survival of Human Monocyte-differentiated Macrophages: Role of Mcl-1, Independent of Nuclear Factor (NF)-{kappa}B, Bad, or Caspase Activation J. Exp. Med., July 9, 2001; 194(2): 113 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.L. Stanton and D.P.L. Green A set of 840 mouse oocyte genes with well-matched human homologues Mol. Hum. Reprod., June 1, 2001; 7(6): 521 - 543. [Abstract] [Full Text] [PDF]
|
|
