Genes and Development

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GENES & DEVELOPMENT 22:1107-1109, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis

John M. Perry1 and Linheng Li1,2,3

1 Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA; 2 Department of Pathology, Kansas University Medical Center, Kansas City, Kansas 66160, USA

Recent reports have demonstrated that specific tumor suppressors are important for both maintaining hematopoietic stem cell (HSC) quiescence and preventing leukemia development, suggesting a connection between these two activities. Matsuoka and colleagues (pp. 986–991) have further illustrated this theme by demonstrating that inactivation of the tumor suppressor Fbxw7 leads to HSC depletion by active cell cycling and the initiation of leukemia.

[Keywords: Fbxw7; c-Myc; Notch1; p53; hematopoiesis; T-ALL]]

3 Corresponding author.

E-MAIL lil{at}stowers-institute.org; FAX (816) 926-2023.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1670708.


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Related Article

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
Sahoko Matsuoka, Yuichi Oike, Ichiro Onoyama, Atsushi Iwama, Fumio Arai, Keiyo Takubo, Yoichi Mashimo, Hideyuki Oguro, Eriko Nitta, Keisuke Ito, Kana Miyamoto, Hiroki Yoshiwara, Kentaro Hosokawa, Yuka Nakamura, Yumiko Gomei, Hiroko Iwasaki, Yasuhide Hayashi, Yumi Matsuzaki, Keiko Nakayama, Yasuo Ikeda, Akira Hata, Shigeru Chiba, Keiichi I. Nakayama, and Toshio Suda
Genes & Dev. 2008 22: 986-991. [Abstract] [Full Text] [PDF]





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