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Published online before print April 28, 2008, 10.1101/gad.468308
GENES & DEVELOPMENT 22:1319-1324, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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RESEARCH COMMUNICATION

DNA replication timing of the human β-globin domain is controlled by histone modification at the origin

Alon Goren, Amalia Tabib, Merav Hecht, and Howard Cedar1

Department of Cellular Biochemistry and Human Genetics, Hebrew University Medical School, Ein Kerem, Jerusalem 91120, Israel

The human β-globin genes constitute a large chromosomal domain that is developmentally regulated. In nonerythroid cells, these genes replicate late in S phase, while in erythroid cells, replication is early. The replication origin is packaged with acetylated histones in erythroid cells, yet is associated with deacetylated histones in nonerythroid cells. Recruitment of histone acetylases to this origin brings about a transcription-independent shift to early replication in lymphocytes. In contrast, tethering of a histone deacetylase in erythroblasts causes a shift to late replication. These results suggest that histone modification at the origin serves as a binary switch for controlling replication timing.

[Keywords: Replication timing; chromatin structure; epigenetics; gene expression; development]

Received December 20, 2007; revised version accepted March 17, 2008.

1 Corresponding author.

E-MAIL cedar{at}md.huji.ac.il; FAX 672-2-641-5848.

Supplemental material is available at http://www.genesdev.org.

Article published online ahead of print. Article and publication date are online at http://www.genesdev.org/cgi/doi/10.1101/gad.468308.


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