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Cover Essential developmental roles for BMP and RB proteins. (Top right) Section of testis from Bmp8b homozygous mutant 2-week-old mouse showing a reduction in the proliferation of germ cells and their delayed differentiation. (For details, see Zhao et al., p. 1657.) (Bottom left) Skeletal preparation of p107^-/-;p130^-/- 16.0 d.p.c. mouse embryo stained with alcian blue and alizarin red showing complete lack of ossification of the humerus (h). (For details, see Cobrinik et al., p. 1633.)