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Cover Loss of plectin causes epidermolysis bullosa with muscular dystrophy (MD-EBS). Shown is indirect immunofluorescence staining of skin biopsy material using an antibody against HDl and plectin. Dermal-epidermal junction and cytoplasm of epidermal keratinocytes is stained with anti-plectin monoclonal antibody 7A8 in normal skin (top, right), but this staining is absent in MD-EBS skin (bottom, left). For details, see McLean et al., p. 1724.)