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Impaired differentiation of p27Kip1
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oligodendrocyte progenitors. Shown are phase-contrast micrographs of
p27-deficient (top) and wild-type (bottom)
precursors in culture following mitogen withdrawal. The majority of
p27
/
progenitors have few simple processes and lack the
highly branched morphology characteristic of mature oligodendroctyes. A
minority of p27
/
precursors that differentiate into mature
oligodendrocytes (middle) are identified by positive
immunoreactivity for myelin basic protein (MBP). (For details, see
Casaccia-Bonnefil et al., p. 2335.)