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Localization patterns of protein components of the synaptonemal complex (SC). (Left) A photomicrograph of an early diplotene mouse spermatocyte nuclei spread stained with antibodies to Cor1 (green) and Syn1 (red). Regions of overlap appear yellow, indicating areas of synapsed chromosomes; green staining indicates areas that have desynapsed. (Right) Two spread nuclei stained with antibodies against Rad51 (green) and Cor1 (red) in late leptotene (top) and early pachytene (bottom) stages of meiosis. Areas of overlap appear yellow. Photomicrographs provided by Peter Moens (York University, Toronto, Ontario, Canada). Left panel reprinted, with permission, from Chromosoma (1997) (Springer-Verlag, New York, NY). (For details, see Roeder, p. 2600.)