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Blood vessel defects in LKLF-null embryos. Shown here is an immunohistochemical analysis of an umbilical vein section from an LKLF-/- mouse embryo using an anti-CD34 monoclonal antibody. The umbilical vein contains vascular endothelial cells, as demonstrated by anti-CD34 reactivity but is dramatically reduced in thickness and displays frank rupture (top). (For details, see Kuo et al., p. 2996.)