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Hoxc13 expression in hair. Shown is the
expression pattern in a mouse hair follicle of
Hoxc13lacZ, a mutant allele that contains
lacZ fused in-frame to the Hoxc13 DNA sequence
encoding the homeodomain, as detected by
-galactosidase staining
(blue), and immunohistochemistry analysis of epidermal type II keratin
(K2.6) intermediate filament protein as detected by anti-K2.6 antibody
(brown). Hoxc13 expression is seen in the rapidly dividing
keratinocytes in the hair bulb and extending up the hair shaft as well
as in the nucleus of the companion layer of the root sheath. (For
details, see Godwin and Capecchi, p. 11.)