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Signaling requirements for mouse pituitary organogenesis; effect
of FGF8 misexpression. Shown are sagittal sections from a wild-type pituitary
gland at E17.5 (left) and from
GSU-FGF8 transgenic embryos
(center and right). Increasing amount of FGF8 activity (right higher than center) leads to progressive
dysmorphogenesis and loss of ventral cell types in the pituitary gland. The
sections are stained with antibodies against growth hormone (left
and center) and ACTH (right). The background is a
schematic drawing of Rathke's pouch at E10.5 with the proposed factors
involved in pituitary organogenesis. (For details, see Trier et al., p. 1691.)