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Signaling requirements for mouse pituitary organogenesis; effect of FGF8 misexpression. Shown are sagittal sections from a wild-type pituitary gland at E17.5 (left) and from GSU-FGF8 transgenic embryos (center and right). Increasing amount of FGF8 activity (right higher than center) leads to progressive dysmorphogenesis and loss of ventral cell types in the pituitary gland. The sections are stained with antibodies against growth hormone (left and center) and ACTH (right). The background is a schematic drawing of Rathke's pouch at E10.5 with the proposed factors involved in pituitary organogenesis. (For details, see Trier et al., p. 1691.)