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Overexpression of CeHSB-1 blocks activation of the heat shock response in Caenorhabditis elegans. Shown is an animal that contains integrated copies of a heat shock protein gene-lacZ fusion (hsp-16::lacZ). Following heat treatment, -galactosidase activity (blue) is detected in intestinal, pharyngeal, nerve ring, and body wall muscle cells (top). Overexpression of CeHSB-1 in body wall muscle cells with the use of an unc-54::hsb-1 fusion results in reduced staining of these cells while -galactosidase activity is observed in other cell types (bottom). (For details, see Satyal et al., p. 1962).