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Fiber type remodeling in skeletal muscle following interruption of the calcineurin/NFAT signaling pathway. Shown is an immunohistochemical analysis of rat soleus muscles from vehicle-treated (top) or cyclosporin A-treated (bottom) intact animals. Fibers expressing fast myosin isoform are stained with antibodies against fast myosin heavy chain (red). Nuclei are counterstained with Hoechst 33342 to visualize the DNA (blue). Treatment with cyclosporin A, a specific inhibitor of calcineurin, promotes slow-to-fast muscle fiber transformation. (For details, see Chin et al., p. 2499.)