Genes & Development -- Table of Contents (September 15 1998, 12 [18])

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Volume 12, Issue 18: September 15, 1998 [Index by Author] [Cover Caption]

Other Issues:

Reviews

Research Papers

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Reviews:

George F. Jr. Sprague: Control of MAP kinase signaling specificity or how not to go HOG wild
Genes Dev. 1998 12: 2817-2820. [Full Text] [PDF]

Robert H. Arch, Richard W. Gedrich, and Craig B. Thompson: Tumor necrosis factor receptor-associated factors (TRAFs) $---$ a family of adapter proteins that regulates life and death
Genes Dev. 1998 12: 2821-2830. [Full Text] [PDF]

Research Papers:

Kazuyasu Sakaguchi, Julio E. Herrera, Shin'ichi Saito, Toru Miki, Michael Bustin, Alex Vassilev, Carl W. Anderson, and Ettore Appella: DNA damage activates p53 through a phosphorylation-acetylation cascade
Genes Dev. 1998 12: 2831-2841. [Abstract] [Full Text] [PDF]

Saïd Sif, P. Todd Stukenberg, Marc W. Kirschner, and Robert E. Kingston: Mitotic inactivation of a human SWI/SNF chromatin remodeling complex
Genes Dev. 1998 12: 2842-2851. [Abstract] [Full Text] [PDF]

Michael J. Pikaart, Félix Recillas-Targa, and Gary Felsenfeld: Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
Genes Dev. 1998 12: 2852-2862. [Abstract] [Full Text] [PDF]

Nynke Gillemans, Rita Tewari, Fokke Lindeboom, Robbert Rottier, Ton de Wit, Mark Wijgerde, Frank Grosveld, and Sjaak Philipsen: Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the $beta$ -globin locus control region in vivo
Genes Dev. 1998 12: 2863-2873. [Abstract] [Full Text] [PDF]

Sean M. O'Rourke and Ira Herskowitz: The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae
Genes Dev. 1998 12: 2874-2886. [Abstract] [Full Text] [PDF]

Lee Bardwell, Jeanette G. Cook, Deepak Voora, Daniel M. Baggott, Anthony R. Martinez, and Jeremy Thorner: Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK
Genes Dev. 1998 12: 2887-2898. [Abstract] [Full Text] [PDF]

David S. Franklin, Virginia L. Godfrey, Hayyoung Lee, Grigoriy I. Kovalev, Robert Schoonhoven, Selina Chen-Kiang, Lishan Su, and Yue Xiong: CDK inhibitors p18^INK4c and p27^Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
Genes Dev. 1998 12: 2899-2911. [Abstract] [Full Text] [PDF]

Marco Milán, Fernando J. Diaz-Benjumea, and Stephen M. Cohen: Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function
Genes Dev. 1998 12: 2912-2920. [Abstract] [Full Text] [PDF]

Eric C. Greene and Dorothy E. Shippen: Developmentally programmed assembly of higher order telomerase complexes with distinct biochemical and structural properties
Genes Dev. 1998 12: 2921-2931. [Abstract] [Full Text] [PDF]

Kim S. McKim and Aki Hayashi-Hagihara: mei-W68 in Drosophila melanogaster encodes a Spo11 homolog: evidence that the mechanism for initiating meiotic recombination is conserved
Genes Dev. 1998 12: 2932-2942. [Abstract] [Full Text] [PDF]

Anke Reinders, Niels Bürckert, Thomas Boller, Andres Wiemken, and Claudio De Virgilio: Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase
Genes Dev. 1998 12: 2943-2955. [Abstract] [Full Text] [PDF]

Brian A. Desany, Annette A. Alcasabas, Jeffrey B. Bachant, and Stephen J. Elledge: Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway
Genes Dev. 1998 12: 2956-2970. [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

The chicken $beta$ -globin insulator protects a transgene from epigenetic silencing in a cell culture system. Shown here are twomodels illustrating possible mechanisms of insulator-mediatedprotection of transcriptional activity. Paired insulators areshown to maintain an active chromatin environment over the transgenebetween them by excluding transcriptional repressive complexesthat include methyl CpG-binding proteins (M), histone deacetylases(D), or any other components (top). Alternatively, insulatorsmaintain an activated chromatin environment by sequestering transcriptionalactivators, such as histone acetylases (A) within the transgene(bottom). (I) Insulator; (P) promoter; (En) enhancer. (For details,see Pikaart et al., p. 2852.)