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HIV-1 Vpr colocalizes with nuclear pores in human cells. Shown is an optical section of a HeLa cell nucleus expressing Vpr. The superimposition of nuclear pore staining (green), as detected by immunofluorescence staining with mAb419, which recognizes a subset of nucleoporins, and HA epitope-tagged Vpr (red), as detected by immunofluorescence staining with antibodies against HA epitope, is shown in yellow. DNA staining is shown in blue. (For details, see Vodicka et al., p. 175).