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Expression and phenotypic analysis of CBP-1 in Caenorhabditis elegans. Shown are Nomarski images of wild-type (top left) and cbp-1 mutant (top right) embryos. The mutant embryo produces many small cells and shows no evidence of mesodermal, endodermal, or hypodermal tissue organization. The small cells are reminiscent of neuronal cells, and immunostaining with antibodies against UNC-86, a neuronal differentiation-specific protein, of wild-type (bottom left) and cbp-1 (bottom right) reveals an increase in the number of neuronal precursors in mutant embryos. (For details, see Shi and Mello, p. 943.)