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Mutations affecting GalR repressosome formation. Shown here is a model of the GalR dimer with the location of mutations affection repressosome formation. The -carbons of the amino acids identified genetically are shown in red. The location of site-directed mutations, which specifically disrupted looping-mediated repression are shown in orange. -Carbons of nonconservative site-directed mutations that had no effect on looping-mediated repression are shown in green. (For details, see Geanacopoulos et al., p. 1251).