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Cerebellar abnormalities in NeuroD (ND)
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Tg mice. Shown here are parasagittal sections of cerebella from wild-type (left) or Nd
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Tg (right) mice taken at postnatal day 30 and stained with X-gal to detect neuroD
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lacZ+ cells. NeuroD-null mice die shortly after birth due to severe neonatal diabetes. The lethal phenotype of NeuroD
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mice is rescued with a neuroD transgene expressed under the control of the insulin promoter. X-gal staining in the granular layer shows a severe granule cell depletion in all of the lobules but to different extents between anterior and posterior lobules. (For details, see Miyata et al., p. 1647).