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The Purkinje onconeural antigen cdr2 colocalizes with c-Myc in rat cerebellar Purkinje neurons. Shown here is a fluorescent microscopic image of a section of adult rat cerebellar cortex where cdr2 (green) is visualized with cerebrospinal fluid from a patient with paraneoplastic cerebellar degeneration, which recognizes the cdr2 antigen. Immunofluorescent detection of c-Myc (red) demonstrates colocalization (yellow) of the two proteins in the cytoplasm of adult neurons. The nuclei of granule cells are visualized with DAPI to detect the DNA (blue). (For details, see Okano et al., p. 2087.)