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Vascular remodeling defects in Notch mutants embryos. Shown here are yolk sacs from Notch 1^+/ (top) and Notch 1^/ (bottom) embryos stained with antibodies to PECAM-1, a marker specific for vascular endothelial cells. In the Notch 1^/ mutant, the primary vascular plexus develops normally but fails to undergo remodeling to form the vessels of the mature yolk sac. (For details, see Krebs et al., p. 1343; see a related manuscript by Shutter et al., p. 1313.)