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Solution structure of the Drosophila Doublesex (DSX) DM domain. Shown here is a stereo image of the DM domain as outlined in schematic form. The main chain structures are aligned according to the main chain atoms of residues 41-81. The sites nucleate a unified globular domain containing two
-helices. The position of the two bound Zn2+ atoms are shown as red spheres. This novel intertwined zinc finger module targets the minor groove of B-form DNA and binds without bending the DNA. (For details, see Zhu et al., p. 1750.)