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The short amidated peptide HEADY is a potent inducer of apical fate in basal metazoans. Shown here is a secondary axis induced by HEADY peptide after lateral transplantation in Hydra. Donor tissue was treated with HEADY and labeled using fluorescent latex beads prior to transplantation into the untreated, unlabeled host. HEADY acts as a developmental switch to pattern the apical-basal axis of Hydra, providing a first insight into how initial assymmetry is specified in basal metazoans. (For details, see Lohmann et al., p. 2771.)