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CBP has tumor-suppressing activity. Shown here is a histological analysis of a histiocytic sarcoma from a CBP heterozygous mouse. Tumors of hematologic origin developed in CBP+/
animals but not in wild-type littermates or in p300+/
animals. Analysis of the CBP locus revealed a loss of heterozygosity, with specific loss of the wild-type allele and retention of the disrupted allele (not shown). (For details, see Kung et al., p. 272.)