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Nuclear compartmentalization as a mediator of chromatin remodeling. Shown here is a fluorescent in situ hybridization analysis of the localization of the human -globin locus in interphase T-MEL (top) or 2-5 MEL (bottom) nuclei. The DNA is shown in blue, the centromeres in red, and the -globin locus in green. In the 2-5 MEL hybrid, the -globin locus is found away from the centromeres, regardless of the -globin transcription. In contrast, the -globin locus is in close proximity to centromeres in T-MEL hybrids harboring a silent, closed locus. (For details, see Schübeler et al., p. 940.)