|
|
|
![]() Other Issues: |
|
||||||
Nuclear
-catenin specifies hair cell fate in the postnatal hair cycle. Shown here is an early stage of the postnatal hair cycle during which stem cells give rise to new downgrowths that will eventually produce a new hair. Immunofluorescence analysis using antibodies directed against
-catenin (green) shows membrane-associated staining in all epidermal cells, and nuclear
-catenin accumulation in a crescent of cells abutting the dermal papilla. Blocking
-catenin activity with expression of a
Nlef1 transgene causes a transdifferentiation into oil-producing cells. (For details, see Merrill et al., p. 1688.)