Genes & Development -- Table of Contents (August 1 2001, 15 [15])

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Volume 15, Issue 15: August 1, 2001 [Index by Author] [Cover Caption]

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Perspectives

Research Papers

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Perspectives:

Timothy F. Osborne: CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin
Genes Dev. 2001 15: 1873-1878. [Full Text] [PDF]

Stephen A. Duncan and Alistair J. Watt: BMPs on the road to hepatogenesis
Genes Dev. 2001 15: 1879-1884. [Full Text] [PDF]

Research Papers:

Elise Lamar, Gisèle Deblandre, Daniel Wettstein, Volker Gawantka, Nicolas Pollet, Christof Niehrs, and Chris Kintner: Nrarp is a novel intracellular component of the Notch signaling pathway
Genes Dev. 2001 15: 1885-1899. [Abstract] [Full Text] [PDF]

Sheila Vidal, Ranjiv S. Khush, François Leulier, Phoebe Tzou, Makoto Nakamura, and Bruno Lemaitre: Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF- $kappa$ B-dependent innate immune responses
Genes Dev. 2001 15: 1900-1912. [Abstract] [Full Text] [PDF]

Chengkai Dai, Joseph C. Celestino, Yoshifumi Okada, David N. Louis, Greory N. Fuller, and Eric C. Holland: PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
Genes Dev. 2001 15: 1913-1925. [Abstract] [Full Text] [PDF]

Ana M. Fernández, Jason K. Kim, Shoshana Yakar, Joëlle Dupont, Catalina Hernandez-Sanchez, Arthur L. Castle, Jonathan Filmore, Gerald I. Shulman, and Derek Le Roith: Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes
Genes Dev. 2001 15: 1926-1934. [Abstract] [Full Text] [PDF]

Sukesh R. Bhaumik and Michael R. Green: SAGA is an essential in vivo target of the yeast acidic activator Gal4p
Genes Dev. 2001 15: 1935-1945. [Abstract] [Full Text] [PDF]

Erica Larschan and Fred Winston: The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4
Genes Dev. 2001 15: 1946-1956. [Abstract] [Full Text] [PDF]

Tracy L. Johnson and John Abelson: Characterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing system
Genes Dev. 2001 15: 1957-1970. [Abstract] [Full Text] [PDF]

Liming Xiong, Byeong-ha Lee, Manabu Ishitani, Hojoung Lee, Changqing Zhang, and Jian-Kang Zhu: FIERY1 encoding an inositol polyphosphate 1-phosphatase is a negative regulator of abscisic acid and stress signaling in Arabidopsis
Genes Dev. 2001 15: 1971-1984. [Abstract] [Full Text] [PDF]

Pedro Gil, Elizabeth Dewey, Jiri Friml, Yunde Zhao, Kimberley C. Snowden, Jo Putterill, Klaus Palme, Mark Estelle, and Joanne Chory: BIG: a calossin-like protein required for polar auxin transport in Arabidopsis
Genes Dev. 2001 15: 1985-1997. [Abstract] [Full Text] [PDF]

Jennifer M. Rossi, N. Ray Dunn, Brigid L.M. Hogan, and Kenneth S. Zaret: Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm
Genes Dev. 2001 15: 1998-2009. [Abstract] [Full Text] [PDF]

Eva Reissmann, Henrik Jörnvall, Andries Blokzijl, Olov Andersson, Chenbei Chang, Gabriella Minchiotti, M. Graziella Persico, Carlos F. Ibáñez, and Ali H. Brivanlou: The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development
Genes Dev. 2001 15: 2010-2022. [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Nrarp is a novel intracellular component of the Notch signaling pathway in Xenopus. Shown here is a whole-mount in situ hybridizationanalysis of a neural plate stage Xenopus embryo using a probedirected against the neuronal marker $beta$ -tubulin (dark blue). InXenopus, Notch signaling negatively regulates the number of primaryneurons that form in the neural plate through the process of lateralinhibition. At the two-cell stage, the embryo shown was injectedin the animal pole with Nrarp RNA. Overexpression of Nrarp (top,inset) induces the formation of additional primary neurons, suggestingthat Nrarp negatively regulates Notch signaling. (For details,see Lamar et al., p. 1885.)